 This study compared the clinical and morphological characteristics of patients who died from COVID-19 during three different waves. It found that the incidents of certain complications such as thrombosis, hemorrhage, necrosis, and myocarditis decreased over time. Additionally, it observed that the presence of CD8, T, killer cells increased in the myocardium of patients with COVID-19. However, the connection between myocarditis and SARS-CoV-2 infection remains unclear. This article was authored by Lubov Borisovna Mitrofanova, Igor Aleksandrovich Makarov, Andrey Nikolievich Gorshkov, and others.