 Peroxizome proliferate-activated receptors, PPA-Rs, are a family of nuclear hormone receptor superfamily subtypes that regulate energy homeostasis and metabolic function by affecting triglyceride levels, insulin sensitivity, glucose metabolism, fatty acids metabolism, inflammation, cancer, lung diseases, neurodegenerative disorders, fertility or reproduction, pain, and obesity. This article was authored by Sandeep Tyagi, Paras Gupta, Arminder Singh Sani, and others.