 This study applied machine learning techniques to assess the impact of specific factors on the size and PDI of liposomal nanoparticles. The results demonstrated that optimizing independent factors significantly affects the characteristics of liposomal nanoparticles and the potential of ensemble learning as a decision support system for identifying the best liposomal formulation. Further studies are recommended to explore other independent factors affecting liposomal nanoparticle characteristics. This article was authored by Benjamin Hosaini, Mammoud Reza Jafari, Amin Golubpur, and others.