Multi Scale Modeling of Chromatin and Nucleosomes





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Published on Feb 11, 2016

Strategic Programs for Innovative Research Field 1
Supercomputational Life Science

Double-stranded DNA in which genetic information is encoded is folded into compact protein-DNA complex structures, called “chromatin", in a nucleus of cell. When DNA is transcribed into RNA for gene expression, chromatin has to be in relaxed conformations. These conformational changes are regulated by chemical modifications of histones and so on. To study the complicated mechanism of life, three-dimensional structures of nucleosomes that compose the chromatin were constructed virtually and molecular dynamics (MD) simulations based on physical laws such as the equation of motion were conducted using the K computer. Such MD calculations enable us to simulate and observe dynamic behaviors of chromatin structures precisely.

Simulations of biomolecules in cellular environments
Graduate School of Medical Life Science, Yokohama City University
Mitsunori Ikeguchi

Quantum Beam Science Center
Japan Atomic Energy Agency
Hidetoshi Kono, Hisashi Ishida, Kimiyoshi Ikeda, Shun Sakuraba

Graduate School of Science, Kyoto University
Shojo Takada, Tsuyoshi Terakawa, Yusuke Takagi, Le Chang

Art Direction
Transistor Studio

Yui Morishita

Production Management
Cybernet Systems Co.,Ltd.

3DCG Animation Design and Creation

If you wish to use this material, please see: http://www.scls.riken.jp/en/informati...

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