 The study investigates the content themes and writing strategies used in anti-vaccine misinformation about COVID-19 and their impact on virulity on social media. The results show that safety concerns are the most prominent content theme while mimicking of news and scientific reports via format and language features is a positive predictor of likes. The study contributes to a richer understanding of how to counter anti-vaccine misinformation on social media to reduce vaccine hesitancy. This article was authored by Cindy Singh Biknai, Rita Gil Singh, and Lu Yao.