 Manjiferin is a natural compound with anti-cancer properties. However, its low water solubility and poor oral bioavailability have limited its use as a therapeutic agent. To overcome these limitations, researchers have developed a novel phospholipid-based microemulsion system to deliver manjiferin topically. The resulting nanoparticles are small, less than 150 nanometers, and highly loaded with manjiferin, greater than 75 percent. These particles also exhibit a controlled release pattern, which enhances their anti-cancer activity by up to four times compared to free manjiferin. Furthermore, the particles increased cellular uptake and prolonged residence time in skin tissue suggests that they could offer a safe, topical, and effective treatment option for breast cancer. This article was authored by Faisal K. Al-Khalifi, of Tabalam, Ahmed Ifada, and others.