 This paper summarizes the experiences of CTSA hubs during the COVID-19 pandemic. The authors surveyed these hubs and found that most have implemented measures to protect their staff and participants from exposure to the virus. These measures include limiting physical contact between people, restricting travel, and implementing social distancing protocols. Additionally, many hubs have suspended or modified research activities, such as requiring remote participation and using virtual laboratories. Finally, the authors discussed the importance of maintaining communication and collaboration among researchers, as well as the need to reevaluate research protocols when the pandemic ends. This article was authored by Patrick A. Flume, L. E. F. Burberry, Laura Vieira, and others.