 I'd like to take you through another interesting scenario, where a 13-year-old boy by named Murunmai Dev Chandra from Bangladesh came to a hospital and met Dr. Poonam Patil, who's a senior consultant in medical oncology, with a severe swelling of the right thigh and the knee joint and inability to move or walk since nearly two months of duration. This 13-year-old boy who came with a large tumor in his leg and it was painful, swollen and when we examined him, we found that he even had a pathological fracture of the leg. On further evaluation, we found out that he was actually having this progressive swelling in the right lower thigh and the knee, which was rapidly progressing over nearly one and a half to two months time and it had left him bedridden, in fact. So, all the relevant investigations were done and we found out that he was actually suffering from bone cancer, a type called osteosarcoma, which is basically a very aggressive type of cancer. What is unfortunate in the situation is that he had a fracture at the lower part of the thigh bone, that is the femur bone and this complicated a lot of things because there was an extensive tumor spillage and the tumor was was nearly covering up more than 90% of the thigh and the knee component. Still, his PET CT scan indicated that there was no other disease focused anywhere else. So, considering that we would like to give him a benefit of treatment, madam started him on chemotherapy. Now, when this child was treated, we gave him chemotherapy and then took him up for surgery. To our delight, the tumor had responded very well and not only we were able to conserve his limbs, but also the pathology report showed that there was no viable tumor cell in the specimen. After nearly three cycles of chemotherapy and a lot of ups and downs, we actually saw that he had responded pretty well to the chemotherapy regimen on both clinical and radiological aspects. When he presented to us, the situation was so bad that we felt that, you know, we may have to do an emergency amputation to save his life because the tumor component and the spillage was extensive so much so that thinking about saving the limb was pretty difficult or pretty challenging and we were more worried about saving the life because of the enormity of the disease burden in the thigh. But as I said, as a pleasant surprise and the way, you know, the child took the treatment, how strong he was and motivated his family was, that there was an excellent response, you know, under the effect of chemotherapy and actually the bone which was fractured healed back to a certain extent. So then we took a decision to go back, revisit the whole scenario and planning and we counseled the parents and the child and we actually went ahead with saving the limb of the child. So a surgery was done wherein the lower third component of the femur and the knee component was removed and we also saw interoperatively that the spillage was contained so the chemotherapy effect was excellent and after this we actually put across tumor component processes replacing the lower part of the thigh and the knee joint and again it was very reassuring and encouraging for us that the child walked from the second day of the surgery itself. So to have a child who's not walked for nearly five months and who had a very, you know, bleak prospect of his limb being saved to see a great response and nearly 100 percent kill rate as they said on chemotherapy, on evaluation, the specimen is, you know, a really heartening thing to see. What's more important from this scenario is that this again could have been awarded if the child had come early to us. We were in Bangalore at the time. We didn't know anything for the first time. So here we saw that all the doctors and nurses were so friendly and helped each other a lot. Often we neglect bone tumors and we don't treat them properly but like this child we were rewarded with success. So bone cancers are very aggressive and the earlier they come the better the results so please come early, get evaluated and get the best treatment. Thank you.