 Gentamicin is a commonly used antibiotic which can cause serious side effects such as nephrotoxicity. Losartan and magnesium sulfate have been shown to reduce these side effects when administered separately or in combination. Losartan has been found to decrease oxidative stress and improve renal function while magnesium sulfate has been shown to increase antioxidants and improve renal blood flow. Together, they may be able to reduce the severity of Gentamicin induced nephrotoxicity. This article was authored by Fatemay Korkanajad-Guriay, Tahira Safari, Abbas Ali-Niazzi, and others.