 I'm Laurie Passmore, a group leader at the MRC Laboratory of Molecular Biology in Cambridge. The main focus of my research is to understand how polyatails are added and removed from mRNAs and also DNA cross-link repair, and we use a structural biology and biochemical reconstitution approach. We use cryoEM to determine structures of the proteins involved, and this really gives us insight into mechanism. In the past few years, it's become possible to determine structures at high resolution for many, many proteins, and that's been really exciting. Going forward, I think the ability to look at time-resolved processes and things in getting more different types of structures is where we're headed.