 The implementation of e-health systems has been increasing worldwide, but there remains a tension between cost-effective delivery and successful implementation. This review provides an update and re-analysis of a systematic review of the e-health implementation literature, resulting in accessible and usable recommendations for anyone involved or interested in implementing e-health. The study includes 44 reviews from North America and Europe, representing various e-health technologies and healthcare settings. Factors important for implementation were identified at multiple levels, including individual technology, outer setting, inner setting, and individual health professionals. The review provides a synthesis of the literature that acknowledges the complexity of e-health implementation and offers practical recommendations for practice. Additionally, this review identifies areas where additional research is necessary to further test the consolidated framework for implementation research. This article was authored by Jamie Ross, Fiona Stevenson, Ray Solow, and others. We are article.tv, links in the description below.