 Good morning everyone, my name is Pazhula Suresh from Katori Medical College. My e-paper is Regarding Spectrum of Involvement of Hypoxic Hypoxia Cancephalopathy in Children and Adults. Introduction, Hypoxic Hypoxia Cancephalopathy in Adults and Older Children, also known as Global Hypoxic Hypoxia Cancephalopathy, is seen in many settings and often has a devastating neurological sequence. Hypoxic Hypoxemic Cerebral Injury occurs at any age. All the ideologies are significantly different. Older children most commonly due to drowning and asphyxiation and adults often result in result of cardiac arrest or cerebral vascular disease with secondary hypoxemia or hypoperfusion. The aims and objectives of this study is to demonstrate MRA findings and establish the difference in patterns of HIE in term, pre-term and adult population. Seven patients presenting with features of HIE of different age groups were studied using 1.5 TES MRA. High resolution T1, T2 weighted serous sections were obtained in axial and sagittal pains. Diffusion weighted images and continuous fast player images were also obtained in coronal planes. The results of the study is to the MRA imaging findings of HIE in the subjects of varying age groups and severity were evaluated. In pre-term and in new units, the common findings include bilateral symmetrical preventive gliosis and even external outlines of integral and thinning of white matter. In term new units, acute and severe hypoxia results in damage to grave matter, especially in basal ganglia and thalamus. Extensive multi-cystic involvement of white matter quite often accompanied by necrotic cavities is typical for prolonged and severe hypoxia. In adults, involvement of grave matter hippocampus cerebellum is noted. Waterside influx is also noted in mild to severe asphyxia. T2 axial and flare axial and coronal flare images showing confluent hyperintensity involving bilateral periventricular deep white matter on T2 and flare images with white matter volume loss and dysmorphic shape of lateral ventricles such as periventricular leukomalacia and T2 sagittal and flare axial and coronal images showing hyperintensity series in bilateral periventricular white matter with loss of white matter volume and associated thinning of body of corpus colosum seen in the sagittal section such as changes of periventricular leukomalacia. Flare at the level of ventricles and capsule ganglionic region and diffusion weighted imaging at the level of capsule ganglionic region and corresponding ADC maps show hyperintensity signaling signals involving bilateral insular cortex, bilateral thalamus ganglionic regions which appears bright on DWI and dark on ADC showing diffusion restriction. MR findings of HIE in subjects of varying group and severity were evaluated. In preterm new units, the common findings include bilateral symmetrical periventricular glaiosis and even external outlines of ventricle and thinning of white matter. In term new units, acute and severe hypoxia results in damage to white matter especially in basal ganglion and thalamus. Extensive multi-cystic involvement of white matter quite often accompanied by necrotic auteus is typical for a prolonged and severe hypoxia. In adults involvement of gray matter hippocompress and cerebellum is noted. Water-striped infax is also noted in mild to severe asexia cases. Conclusions, regulation in HIE reflects delayed cascade of humans in response to oxygen deprivation in brain. The MR findings of HIE is highly variable and depends upon various factors including brain maturity at the time of insult and severity. Thank you.