 The nanoparticles can be useful as reservoirs of lipophilic drugs to deliver them in the stratum corneum, becoming an important strategy to control their permeation into the skin. The penetration and transport extent of those systems through the skin depends on the ingredients chemical composition and the encapsulation mechanism influencing the drug release on the size of nanoparticles and the viscosity of the formulations. This article was authored by Silvia Escuterres, Marta P. Alves and Adriana R. Pullman.