 This study examined the evolutionary history of a large family of bacterial response regulators finding that they had undergone a structural transformation from helix turn helix to winged helix. The authors hypothesized that this change allowed for increased DNA binding specificity which could be beneficial for the organism. Their approach was able to identify this structural transition in the protein family providing insight into how such transformations occur in other protein families. This article was authored by Devlina Chakravati, Shweta Srinivasan, Lee's Kin Swint Cruise, and others.