 The study examined the effects of high fat diet, HFD, on females and males. It was found that females were better protected from HFD, induced metabolic alterations and hearing impairments than males. Additionally, females had higher serum adiponectin concentrations and increased cochlear and liver adipo R1 expression, while males showed increased core stress granules components and cochlear inflammation. This article was authored by Sir John Kim, a concha gadbae, RR Liu, and others.