 The study presents a novel extracellular matrix hydrogel at exosomes, ECM at Exo, that incorporates adipose-derived mesenchymal stem cell-derived exosomes into an extracellular matrix hydrogel, which forms a hydrogel at physiological temperature upon local injection into the wound site. The ECM at Exo enables sustained release of ADSC exos from the ECM hydrogel, promoting angiogenesis, collagen deposition, cell proliferation, and migration, thereby accelerating the wound healing process. This innovative therapeutic approach offers a new avenue for wound healing via a biological hydrogel with controlled exosome release. This article was offered by Yenling Song, Yuchanyu, Sinisu, and others.