 The results of our study suggest that amicacin, urtopenum, and meropenum are effective intravenous options for treating pediatric urinary tract infections caused by E. coli in Saudi Arabia. Additionally, cephalosporin, sephuroxem, amoxicillin slash clavulanic acid, and nitrofurantoin are suitable oral choices. There have been no significant changes in antimicrobial susceptibility patterns during the COVID-19 pandemic. Further research is needed to assess potential pandemic-related alterations. This article was authored by Ibrahim Altamimi, Abir Al-Mazid, Sami Al-Shemri, and others.