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Published on Feb 19, 2014
Table of Contents: 00:09 Lecture 5.3: Putting the pieces together Genome Sequencer -- Part 3 00:46 Outline 01:17 Recall: Sequencing by synthesis 03:42 Homo-polymer Error (~3% for N=5) 08:05 Signal and Reference Well 09:18 Scaling of Cross-Talk 10:17 Reliability: Salt Instability addressed 13:14 Scaling challenges of Sequencing Chips 14:05 Properties of Signal and Noise Scaling 17:08 Putting together the pieces 20:30 Conclusions
This course provides an in-depth analysis of the origin of the extra-ordinary sensitivity, fundamental limits, and operating principles of modern nanobiosensors. The primary focus is the physics of biomolecule detection in terms of three elementary concepts: response time, sensitivity, and selectivity. And, it potentiometric, amperometric, and cantilever-based mass sensors to illustrate the application of these concepts to specific sensor technologies.