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nanoHUB-U Nanobiosensors L5.3: Putting the pieces together - Genome Sequencer III

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Published on Feb 19, 2014

Table of Contents:
00:09 Lecture 5.3: Putting the pieces together Genome Sequencer -- Part 3
00:46 Outline
01:17 Recall: Sequencing by synthesis
03:42 Homo-polymer Error (~3% for N=5)
08:05 Signal and Reference Well
09:18 Scaling of Cross-Talk
10:17 Reliability: Salt Instability addressed
13:14 Scaling challenges of Sequencing Chips
14:05 Properties of Signal and Noise Scaling
17:08 Putting together the pieces
20:30 Conclusions

This video is part of the nanoHUB-U course "Principles of Electronic Nanobiosensors". (https://nanohub.org/courses/PEN)

This course provides an in-depth analysis of the origin of the extra-ordinary sensitivity, fundamental limits, and operating principles of modern nanobiosensors. The primary focus is the physics of biomolecule detection in terms of three elementary concepts: response time, sensitivity, and selectivity. And, it potentiometric, amperometric, and cantilever-based mass sensors to illustrate the application of these concepts to specific sensor technologies.

For more details see http://nanohub.org/u

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