 Cyclodextrin-based nanosponges are a novel type of nanoscale delivery system consisting of cross-linked cyclodextrin polymers with a three-dimensional network. These polymers can be modified to create porous insoluble nanoparticles with either a crystalline or amorphous structure, or they can have swelling properties. Their polarity and size can also be adjusted by varying the type of cross-linker and degree of cross-linking. Additionally, these sponges can be functionalized for site-specific targeting, making them a safe and biodegradable material with negligible toxicity on cells and animals. Furthermore, they can form complexes with different types of lipophilic or hydrophilic molecules, allowing for controlled release of entrapped molecules. Finally, they can be used to improve the aqueous solubility of poorly water-soluble molecules, protect degradable substances, obtain sustained delivery systems, or design innovative drug carriers for nanomedicine. This article was authored by Francesco Trotta, Marco Zanetti, and Roberta Cavalli. We are article.tv, links in the description below.