 Hello everyone. I'm Khan Jumam Parvez, first year resident at Dr. D. Y. Parthi Hospital, Kulapur. I'd like to thank Indian radiologist for giving me this opportunity to present this paper. And I'd like to thank my mentor Dr. Nitin Vardwani, HOD department of railroad abuses, and all of my faculty at Dr. D. Y. Parthi Hospital. My case series is on neurodegenerative disorders, aim and objective to describe MRI features of neurodegenerative disorders and to describe other differentials of atypical aging changes. Introduction. As the brain necessarily ages, it displays a spectrum of age related neuroimaging features, including atrophy and changes in life matters. It is essential to be knowledgeable about common distinctions for atypical imaging findings, as these may indicate the presence of neurodegenerative disorders and other diagnosis. Imaging findings characteristic of important distinctions include multiple system atrophies, apricotinitis, T2 flare, hypointense, shrunken vitamin with hyperintense lateral limb, multiple system atrophy cerebellar type, cerebellar atrophy, shrunken pons and medulla with T2 flare, cruciform hyperintensitin pons, progressive supranuclear palsy, midbrain atrophy with concave superior surface, corticobasal degeneration, cortical atrophy with atrophy of bilateral basal ganglia. Other important distinctions include normal pressure, hyperellus, ventriculomegaly out of proportion to sulcal enlargement, ventriculosulcal disproportion, vascular dementia, multifocal infarct with consulate T2 flare, white matter hyperintensity, and T2 star blooming methods, patients exhibiting brain atrophy and white matter alterations on MRI scan and event evaluation, including analysis of atrophies. Including analysis of the clinical history and examination results. Among these, those displaying clinical and imaging characteristics indicative of neurodegenerative disorders were identified and the features delineated. Two important differentials of atypical aging changes were also included. Results Case 1, T2 weighted images show generalized cerebellar atrophy with prominence polia and posterior posa system. T2 societal sections shows atrophy of midbrain and pons. T2 axial sections shows mild generalized cerebral atrophy. Most likely diagnosis is multiple system atrophy cerebellar type. Case 2, T2 and flare axial images show atrophy of bilateral basal ganglia with prominent perivascular faces along with generalized cerebral atrophy. T2 societal sections shows midbrain atrophy with concave period surface. T2 coronal sections shows atrophy of bilateral basal ganglia with prominent perivascular faces with generalized cerebral atrophy. Most likely diagnosis is quadruple basal degeneration. Case 3, T2 axial images show atrophy of bilateral basal ganglia with prominent perivascular faces along with generalized cerebral and cerebellar atrophy. T2 societal sections shows midbrain atrophy with concave superior surface. T2 coronal sections shows atrophy of bilateral basal ganglia with prominent perivascular faces with generalized cerebral atrophy. Most likely diagnosis is quadruple basal degeneration. Case 2, T2 and flare images show bilateral ventricles dilated with mild cerebral atrophy and periventricular white matter hyperintensity. T2 coronal and societal sections show dilated lateral ventricles and third ventricle with periventricular white matter hyperintensity. Most likely diagnosis is normal pressure hydrocephalus. Case 5, T2 and flare axial images show bilateral periventricular white matter hyperintensity. Susceptibility evaluated imaging, axial image show areas of blooming digestive oblique. Most likely diagnosis is vascular dementia. Discussion based on clinical assessment and imaging findings. It is essential to consider differentials that go beyond typical age related changes and chronic white matter systemic alterations. This helps prevent missed diagnosis and ensures accurate evaluation. These are my references. Thank you.