 This research paper examines the similarities between osteosarcoma in humans and dogs, and how it can provide insight into the disease. It found that two genes, interleukinate, Illinois 8, and solute carrier family 1, glal hyalfinity glutamate transporter, member 3, SLC1A3, are expressed in both species, but not in all pediatric osteosarcoma patient samples. Expression of these genes in an independent population of pediatric osteosarcoma patients was associated with poor outcome, P equals 0.020 and P equals 0.026, respectively. This suggests that these genes may play a role in the progression of the disease. Additionally, validation of Illinois 8 and SLC1A3 protein expression in pediatric osteosarcoma tissues further supports the potential value of these novel targets. This article was authored by Trish Timothy, Hewitt Stephen, Picky Piero, and others. We are article.tv, links in the description below.