 Due to their increased surface area, extent of swelling and active substance loading capacity and flexibility, nanogels made from natural and synthetic polymers have gained significant interest in scientific and industrial areas. In particular, the customized design and implementation of non-toxic, biocompatible, and biodegradable micro slash nano carriers makes their usage very feasible for a range of biomedical applications, including drug delivery, tissue engineering, and bio-imaging. The design and application methodologies of nanogels are outlined in this review. Additionally, the most recent advancements in nanogel biomedical applications are discussed, with particular emphasis on applications for the delivery of drugs and biomolecules. This article was authored by April Tuntus, Burju Asken, Sevgi Gunger, and others.