 The analysis of gene expression in different human tissues has been made possible by the availability of publicly accessible transcriptomic data. This data provides a framework for understanding the molecular composition of the human body and can be used to generate comprehensive lists of proteins expressed in specific tissues or in a tissue-restricted manner. The consistency between independent genome-wide transcriptome analyses of different tissues suggests that most proteins are present in all tissues, while only a small number are restricted to certain tissues. Furthermore, this data can be used to build genome-scale metabolic models which can be used to analyze cell and tissue functions in both physiological and disease contexts. This article was authored by Mathias Ulland, Bjorn M. Hallstrom, Cecilia Linskog, and others.