 This review provides guidelines for the therapy and rehabilitation of patients with moderate to severe diabetic foot, emphasizing the importance of early detection and vigorous treatment of infections, obtaining bacterial cultures, using various imaging studies to identify diabetic foot, performing surgery when necessary, teaching preoperative rehabilitation, removing necrotic tissue during surgery, treating wounds with suitable dressings, beginning walking as soon as possible, treating. Comorbidities and smoking cessation, and requiring broad-spectrum antibiotics for diabetic foot infections. This article was authored by Chi Young-in, Sung Lim Baek, and Dong I-il Chun.