 Abstract cells have been found to contain liquid-like condensate within their interior, which can be reconstructed in vitro. These condensates interact with membrane-bound organelles, but the exact mechanism behind this interaction is still unknown. In this study, researchers demonstrated how interactions between protein condensates and membranes can produce remarkable morphological changes, providing a theoretical framework to explain them. By manipulating the solution salinity and membrane composition, the researchers were able to observe two distinct wetting transitions, from de-wetting to partial wetting to complete wetting. This process was accompanied by the formation of intricate curved structures which were determined to be caused by the interplay of adhesion, membrane elasticity and interfacial tension. These findings suggest that wetting phenomena play a significant role in cell biology and could potentially be used to create synthetic biomaterials and compartments with tunable properties. This article was authored by Augustin Mangierotti, Nan Nan Chen, Ziliang Zhao and others. We are article.tv, links in the description below.