 Polydemethylsiloxane, PDMS, is an elastic material with excellent optical, electrical, and mechanical properties, making it ideal for various engineering applications. Its biocompatibility has made it popular for biomedical uses, leading to the widespread adoption of soft lithography, a technique that allows rapid prototyping of microstructures from elastic materials like PDMS. Soft lithography has enabled advancements in microfluidics, electronics, and biomedicine. This review summarizes the properties of PDMS and its common treatments, highlighting their suitability for these fields. Examples include microchips for biomedical applications, replicating cardiovascular flows and medical implants. This article was authored by Ems Miranda, Andrew Souza, Paolo Souza, and others.