 Abstract monkeypox has been declared a global public health emergency due to its rapid spread. To combat this threat, researchers have developed two new M-I-N-A vaccines, M-I-N-A-L-N-P and M-I-N-A-B-L-N-P, which are designed to provide protection against the virus. These vaccines were found to be safe and effective in mice, providing protection against both the virus itself and the related virus, VACV. Additionally, these vaccines can also be used to protect against other poxviruses such as smallpox. This research provides hope for developing a safe and effective vaccine against monkeypox and other related viruses. This article was authored by Yi Seng, Zhen Zhong, Fan Liu, and others.