 In this study, we developed a novel stimulus-responsive drug delivery system based on L-licene-functionalized mesoparasilica nanoparticles, MS-at-LIS-N-piece. These particles can respond to changes in pH levels by releasing curcumin, a potent anti-cancer agent, from its internal cavity. This pH-sensitive release mechanism could potentially enable targeted drug delivery to cancerous cells. Furthermore, the MS-at-LIS-N-piece showed excellent cytocompatibility and cellular uptake efficiency, suggesting their potential use in cancer therapies. This article was authored by Matt Happen-Santhamorthy, Vanaraj Ramkumar, Kokola Theropathy, and others.