 So that was a lot of talk about ion channels and voltage sensors. The reason for that is that science frequently works by somebody starting digging into a problem and then we expand around that and this very much expanded around Yasushi Okamura's work. Today we know that there are several other membrane proteins where arginine occurs surprisingly close to the membrane. This one is called 5-Lupoxygenase Activating Protein and appeared a few years ago. Here I have a very very thin transmembrane layer much thinner than I would normally expect. Maybe 15-20 angstroms stick here. And you see here that we have arginines almost inside the membrane. I don't know exactly what the roles of those arginines is but they're likely related to function otherwise we wouldn't see them there. You should just be aware that while we normally would not expect to see charged amino acids they can occur if they are important to function. So when you see it you should guess that this could be relevant for function and go after that.