 In this study, researchers investigated the effects of ischemia on the bladder and its potential underlying mechanisms. They found that ischemia caused detrisor over activity, which is characterized by increased contractions of the bladder wall. This was accompanied by increased levels of certain proteins involved in endoplasmic reticulum stress, autophagy, and apoptosis. Additionally, they observed decreased levels of KEEP-1-NRF-2, which is known to regulate oxidative stress. Sulforofane, a compound derived from broccoli, was able to reduce these changes and restore normal bladder function. The authors concluded that ischemia causes detrisor over activity through multiple mechanisms involving endoplasmic reticulum stress, autophagy, and apoptosis, and that sulforofane may be used as a therapeutic agent to prevent or treat ischemia-induced bladder dysfunction. This article was authored by Huaiqing Tai, Shudong Cheng, Chiang Ting Qian, and others. We are article.tv, links in the description below.