 Vascolytis is a condition caused by inflammation and damage to the blood vessels. It can be triggered by several factors including genetic predisposition, environmental exposure, or immune system dysfunction. Inflammatory cells such as neutrophils and macrophages are responsible for the destruction of the vessel walls. There are two main types of antibodies associated with vascolytis, anti-myeloperoxidase, MPO, and anti-proteinase-3-PR-3. These antibodies are found in the blood of patients with vascolytis, but not in healthy individuals. The kidneys are often affected by this condition, and the severity of the disease depends on how quickly it progresses and how well the patient responds to treatment. This article was authored by Chrissy Mir Gale-Sik, Danico Ljubinovic, and Ivica Horvatik.