 we conducted a large-scale study to investigate sex-specific differences in gene expression levels across human brain regions. Our results suggest that there are significant sex-biased genes in all brain regions, with male-biased genes being more prevalent in the Y chromosome and female-biased genes being more prevalent in the X chromosome. Additionally, male-biased genes were found to be associated with mitosis and cell division, while female-biased genes were associated with synapse formation and maintenance. Furthermore, our findings indicate that female biased genes are more sensitive to adverse drug reactions, suggesting that sex-specific differences in drug sensitivity may contribute to the observed gender disparities in clinical outcomes. This article was authored by Patama Wapisitipan and Anogajoshi.