 Thada has been identified as a type 2 diabetes-associated gene whose function is not fully understood. Here the authors report that Thada deficiency protects mice from hypoglycemia and glucose intolerance by promoting insulin secretion and inhibiting cell apoptosis, suggesting Thada could be explored as a potential therapeutic target for diabetes. This article was authored by Yu Ching-Jong, Shan Han, Song Song Lu, and others.