 This study proposes a control-release nanodelivery system using polycaprolactone, PCL, based electrospond nanofiber mats encapsulating the dapleton and pegetum harmala alkaloid-rich fraction to prevent breast cancer recurrence after tumorectomy. The dual-loaded nanofiber mats demonstrated the highest antiproliferative effects against MCF7 cells with a recorded IC50 of 3.21G-ML and achieved selectivity index, Si, of 20.45 towards cancer cells while conserving normal breast epithelial cells. The combined therapy and PLL at PCL treatment resulted in significantly higher percent cell population in the late apoptosis and necrosis quartiles as compared to all other treatment groups and caused cessation of the cell cycle by trapping more than 90 percent of cells in the sub-G1 phase and reducing the number of cells undergoing DNA synthesis in the S-phase by 15-fold. The findings suggest the potential use of the design nanofiber mats as perfect implants to prevent tumor recurrence after tumorectomy. This article was authored by Nadeke Sittke, Callout K. Arafa, Menal M. M. Abdelhadi, and others. We are article.tv, links in the description below.