 This study analyzed tweets related to anti-obesity drugs between September 2019 and October 31, 2019, and found that the majority of interest among Twitter users is in the efficacy of these treatments. The content that generated the highest frequency of tweets was related to treatment efficacy, with lyriglutide dash, semiglutide dash, and lorcasarin-related tweets accumulating the highest proportion of positive consideration. Semiglutide-related tweets obtained the highest probability of likes and were the most disseminated within the Twitter community. This article was authored by Miguel Angel Alvarezmon, Maria Loverro Valero, Angel Asuncilo del Barco, and others.