 Hello everyone, today I am going to present a short case about listen carefully type one type which is in classic form. A just born baby of three days old presented with facial dysmorphism. There are few facial abnormalities which are described. Tetralgia of allid seizures and they did neuro sonogram. They found some abnormalities that series and they referred for MRI. MRI brain is a classical unappearance. It is showing figure of eight appearance. Further, there is a ventricleomegaly noted. Keohum septum pellucidum seen. Subapandemols is which are likely a germinolytex is also seen which I have seen very commonly with this type of conditions and cortex has a layered pattern. Normally cortex has six layers which we are not able to appreciate in the normal MRI but here you can appreciate because of thicker in size and this is a multi-layer and this is periventicular white matter which is less in size. This is completely smooth brain without any obvious appreciable salsa and gaire. Hence it is a classic listen carefully type one listen carefully. This has got four layers cortex. The layer one is subpial molecular layer layer two is thin outer cortical layer. These two constants only this black line or intermediate signal line. The white line which is continuous all throughout is the third cell sparse zone which contains only no cell heads only the axons disorganized. Inner band is also contains disorganized neurons that is a thick layer. One two three white layer this is fourth layer this is thick band this is much more thicker than the normal usual cortical of six layers. Hence the white matter volume is further reduced. This is bit higher sections where you can see multiple layers with thick cortex inner band with periventicular white matter which is contains water at new born baby which is normal and slight 20 kilo megalee. Even appearance the violation process is different that is going very normally. Here you can see periventicular white matter multi layered cortex the same thing in the upper sections. What you can additionally see there is some T1 hyper intensity in the frontal region. Let's use that like later. A brief review about type one listen carefully. It is a complex which contains agaria, pachychia, even band heterotropia completely listen carefully. This is a spectrum. We have discussed this layers variant of listen carefully. If you don't have any cell sparse layer that is called variant of listen carefully. Corpuscular lozal abnormalities are very commonly accompanies this one and variations in lobes can come between gradient between anterior and posterior. Then you call it as a incomplete listen carefully when you see only partly involving the brain parenchyma. There is excellent genotypic and phenotypic correlation. It exactly translates into the phenotype. There are at least three genetic forms have been described in this condition which we can see in a separate lecture. Midline corpus callosum is not that developed but somehow it is developed. It's not that bad. There is mild dysplasia in the brainstem. So, since we have facial abnormalities we put as a possibility of Miller-Dyker syndrome. Usually when the insult happens between 5 and 22 weeks, all these abnormalities of listen carefully would come. So, what is that periventricular T1 hyperintensity is showing restriction of diffusion and multiple restriction of diffusion. We thought this is a hypoxic ischemic encephalopathy because it's a day 2, day 3 baby. Further adrenals also showing bilateral adrenal haemorrhages right larger than left indicates some perinatal stress for the baby. Another companion case this is 3 months old. So, the layers are much more clear. Layer 1, layer 2, layer 3 and layer 4 spars are less periventricular white matter. Venti-chloromegaly subependymal germinolite exist. Phagraphate appearance completely smooth brain without any obvious appreciation of sulca and gyrate. This exactly translates. Every time you see grade 1 are completely sent carefully. Classical one you will see all this we say consistently in all the patients. I have asked one of our resident Dr. Rajai to draw this one. He has done excellent job. Here is a classical listen carefully with multiple layers appreciable periventricular white matter ventrachloromegaly smooth brain. The slowly the it sulcation gyration improves and it is grade 4. The grade 4 is the better not the worse grade 6 is called band like heterotropia. So, this is agaria, pachygaria, listen carefully complex grading. I try to translate into visually from the available cases from no sulci to decent sulci in the later parts. So, if you have a micro carefully associated with listen carefully then you will call micro listen carefully which is our case. If you have cerebral or hypoglycea associated with listen carefully you will call LCH listen carefully with cerebral or hypoglycea which has a specific genetic association.