 Astazenthin ASX, a type of carotenoid found in nature, has been shown to possess powerful antioxidant activity and protect against several diseases including cancer, diabetes, and cardiovascular disease. Despite its potential benefits, ASX's low water solubility and instability make it difficult to use in clinical settings. Recently, researchers have developed novel drug delivery systems such as nanoparticles, liposomes, nanoemulsions, nanodispersions, and polymer micelles to improve the stability and efficacy of ASX. These systems have been proven to increase the stability and bioavailability of ASX, making them promising candidates for future clinical applications. This article was authored by Xiqian Chen, Xiqian Chen, Jia Yuying, and others.