 Thank you so much. Good morning. Since I'm talking about fasting, I feel like maybe your overnight fast is extending just a little bit with coffee arriving at 10. Yes Fantastic so Hopefully I know my humor comes across in some of these but hopefully it is good FMD or FML talking about my experiences with the fasting mimicking diet Kids made this we played with some fun memes What do we choose FMD fasting mimicking diet? FML raise your hand if you think you know what FML means It's slaying for f my life Yes So when I do this my husband he'll ask. Oh, is it FML week again? I Roll my eyes and get upset at him Thank you so much for coming this morning Today I will share my personal experiences with this fasting mimicking diet But I call FMD and I will describe what typical experiences and results are like I'll describe both the official and homemade versions and the benefits and challenges of each I'll discuss how often FMD is recommended for various groups and I'll identify who is and is not a good candidate for FMD I'll also talk about what you should expect when talking to your doctor about FMD. I hope you find my presentation Interesting useful and maybe even a little bit funny My title is meant to grab your attention while promising that I'll be quite honest with you today As I just said FMD is the abbreviation for the fasting mimicking diet FML is slaying for f my life We're talking about five day fast, so I think it's appropriate. I worked my husband's humor into this actually My family's sarcastic nickname for my FMD. I have no formal association with Prolon the company that sells FMD kits I'm only affiliated with them as a customer However, they did give me permission to use images from their website for this talk. My opinions are my own Two years ago at AHS 17 in Seattle. I found myself in a dire situation My insurance had repeatedly denied continuing my multiple sclerosis Infusion medicine that had stopped new disease progression for over three years I was five months overdue for this powerful infusion medicine And I was pretty terrified of having another disabling exacerbation as I did years earlier My first night at AHS that year. I caught up with my dear friend Rand Akashay She while she was finishing her masters or sorry her PhD in nutrition She told me about a simple yet powerful dietary intervention that could potentially replace my multiple sclerosis infusion Rand is brilliant and she does research for a living Still I needed a second opinion. I Shared Rand's fasting mimicking idea with Rob Wolf The man whose book paleo solution motivated me to lead a more healthful life nine years ago Without hesitation Rob embraced the idea in his presence at AHS I was completely in agreement that this was what I needed to do You know in Rob's present presence you can do anything so charismatic However, just a few weeks later. I won my federal appeal. I won a federal appeal to use a med off label pretty cool so In my own reality without that against me Outside of Robin Rand's presence. I lost motivation to push myself that far out of my comfort zone To be honest, I thought the fasting mimicking diet sounded like torture But time passed oops, oh Time passed and I developed asthma and a partially torn rotator cuff Okay, this might be out of order. I Developed asthma and a partially torn rotator cuff on my dominant shoulder. It was limiting me substantially I couldn't lift any weight over my head. I was drowning. It was bad Then we have the meme when everything is going wrong in your life, but you're used to it This sums up my life. I'm only sharing a small portion of my health issues with you today There's a lot more behind the scenes burning But this this is how I feel I've had countless PT exercises physical therapy to do every day And I had a new asthma pill in this new reality I was living after AHS 17 just trying to Make my shoulder work. I was getting the steroid injections. It wasn't working I was not happy By the way, all these things go away after the fasting mimicking diet Easily, but then it happened My ophthalmologist who I already saw twice a year for two other conditions found a new disease process Scarring my retinas take a look here. They're not supposed to look like this The giant circles on the outside edges are that's that's the Your optic nerve bundle of nerves, that's good. Thank goodness, which with multiple sclerosis I'm lucky to have good optic nerves still But all the other spots around not good The white spots there are called drusen and these drusen fatty deposits in my retinas were a Science some new process was going on which later got diagnosed to stargarts juvenile Macular degeneration because I'm a kid right late onset But it's it's a leading cause of blindness and children under 18. I'm lucky to get it now and not back then So these drusen deposits were multiplying over time I had successfully fought two other conditions that were supposed to take my vision and I was not about to let this new Process limit me. It was time for me to jump in and try the fasting mimicking diet. What did I have to lose? I'm told I'm going to go blind lose my vision Here's an image of the fasting mimicking diet kit from Prolon the one that you can buy online The fasting mimicking diet is based on dr. Walter Longos three decades of research on longevity and health It takes advantage of the fact that our genetics expect both times of feast and famine Today food is available 24-7 and companies like Grubhub are happy to deliver to you night or day This constant state of being overfed is a critical mismatch with our bodies expectations and needs Fasting diets have become popular in recent years time restricted eating and intermittent fasting both provide weight loss and fat burning But prolonged fasting often lasting four to seven days provides weight loss But also changes at the cellular level that increase many many many health markers Prolonged fasting allows our bodies to replace faulty cells and to eliminate harmful autoimmune and cancer cells and for our bodies to create stem cells Fasting for four to seven days even with water is too risky for most people However, Prolon's FMD mitigates that risk and makes a prolonged fast easier to successfully complete Dr. Longos team developed the FDA approved Prolon FMD So more people could reap the benefits of fasting while mitigating the risks The Prolon FMD kit contains five individual boxes one for each day of the fast each box includes the nut-based L bar for breakfast Dry packets to make various soups for lunch and dinner kale crackers olives and a choco crisp L bar for snacks each day's Box also includes a small bottle of diluted glycerin to add to his flavored glycerin raspberry or orange That you add to your water or your mint or hibiscus tea on certain days You also take their multivitamin and or an algal oil omega-3 pill on day one of FMD. You consume 1,100 calories Piece of cake. That's super easy These two through five you'll eat 725 calories. Not terrible Prolon's research states that you'll enter ketosis on day two and you'll begin to burn visceral fat You hydrate well with unlimited water and Decaffeinated tea constantly drinking To reduce your dizziness and risk of falling you add the plant-based glycerin L drink to your fluids to preserve muscle mass During days two through five on day three a tophagy begins and autoimmune and cancer cells begin to get killed off When you're fasting your body works hard to keep your vital systems running. Well, so those cancer and autoimmune cells are left to die Fatigue is common, but fewer than 50 percent of people doing FMD get headaches On day four stem cells begin to increase reaching upwards of 700 percent by the end of the program On day six you finish the fast and you consume liquids in the morning and easy to digest foods the rest of the day On day seven you'll return to your normal healthy diet Dr. Longo recommends a pescetarian diet as a normal healthy diet Fasting in order to create stem cells has moved from Dr. Walter Link Longo's lab at the University of Southern California into the vernacular the last couple of years But what is it really? From the website Prolon FMD comm Sorry for a lot of text here But Prolon is a five-day dietary program that nourishes your body While promoting regenerative and rejuvenating changes including supporting healthy levels of a wide range of physiological markers that contribute to aging such as cholesterol inflammation and fasting glucose It's a program that nourishes your body while promoting regenerative That sure sounds familiar The Prolon fasting mimicking diet mitigates the burden and danger of the water only fasting By providing tasty convenient safe dietary program that does not require ongoing lifestyle changes such as long-term dieting So let's talk results So you the diet supports healthy levels of a wide range of physiological markers that contribute to aging such as Cholesterol inflammation and fasting glucose Yes, we took this picture from the website Prolon FMD But my daughter loves mice, so we won't talk to her about mice and labs She she put cuter pictures here including the meme the meme human guy So we altered that part a little bit But in the preclinical trials They studied yeast mice and humans and to see how they would do with prolonged fasting And you can see the yeast have a better stress resistance longer lifespan with this kind of fasting mice Multisystem regeneration lower adipose Cancer it goes down inflammatory disease go down Immune and cognitive rejuvenation improves and lifespan improves For people the regeneration markers that says risk factors biomarkers Diabetes goes down cardiovascular disease goes down and cancer goes down on this fasting mimicking diet pretty huge global results, so He's on to something he's it makes sense They were finding our match with it from that mismatch of being overfed constantly They're looking at in the human clinical trials Prolon FMD results Were based on three consecutive monthly FMD cycles each cycle is five days long So five days month one five days month two and five days month three The results are reduction in excess weight fasting blood glucose and growth factors associated with DNA damage and aging It protects and rejuvenates your body from cancer and autoimmunity This is the biggest most complicated Chart that I pulled from the website But you have a few more details here the reduced protein amino acid signaling Helps the growth hormone insulin like growth factor one go down Reduced glucose signaling I'll give you a moment to take a look at that But the end result here and the green at the bottom your weight abdominal fat relative body mass improves glucose and slin IGF One improves cholesterol blood pressure all these things. I had a physical last month My doctor has nothing for me. I have a boatload of medical problems But my numbers are good inflammatory markers CRP and stem cells all come out of this So I'm gonna run through several slides pretty quickly. So please don't get stressed I just want to show you specific results of Prolon's clinical trials Participants completed three monthly cycles of FMD with lab work done both before and after So I just want to give you a sense of how positive and global that these benefits are oops So IGF one marker associated with increased mortality and DNA damage to human cells was reduced by 14% Pretty cool graph there before and after C reactive protein levels decreased from 1.5 milligrams per liter to 1 milligram per liter after Participants had resumed their normal diets for five to eight days after cycle three stem cells transient major and significant elevation of stem cell regenerative markers was also observed Even in it even maintained some after your fast as you can see here During the fast your stem cells increased. They say up to 700 percent from their baseline and That's what fixed my my rotator cuff. I'm sure body weight participants lost an average of five pounds in Five days The weight loss came mostly from the abdominal fat shown in a reduction of abdominal fat mass and I completely agree with that my belts had to be taken in Over a one inch lost in waist circumference Lean body mass though is preserved on this and I think that makes the FMD very different than most facts Because generally people complain that they lose muscle on a fast But even though this is very low protein just eight or nine percent protein their studies show that you keep your muscle mass Total cholesterol was reduced nearly 10 milligrams per deciliter with some significant reductions of LDL from 104.9 to 99.2 milligrams per deciliter In obese participants body weight decreased nine pounds Weight remained significantly lower after subjects returned to their normal diet for an average of three months in overweight participants Abdominal weight abdominal fat was reduced by more than seven percent So this diet is changing lives in participants with high cholesterol total cholesterol was reduced by 20 milligrams per deciliter and Low-density cholesterol was reduced by 15 milligrams per deciliter For participants with high blood pressure Cystallic and diastolic blood pressures were reduced by six millimetres of mercury It just normalizes everything. This is what our bodies need. We need a break from eating. We need to reduce the protein briefly Blood pressure remains significantly reduced after subjects returned to their normal diet Even after an average of three months in high-fasting glucose Participants fasting glucose was reduced by over 10 milligrams per deciliter and remained reduced after subjects returned to their normal diet for an average of three months in Participants at an average risk for developing cardiovascular disease see reactive protein between one and three milligrams per liter was lowered More than one milligram per liter Putting them closer to the lowest risk category Almost done with these high-fasting glucose participants Fasting glucose decreased over 10 points even after three months of normal dieting. No wonder my labs were good They weren't bad before but I Mean we all have friends that could could use a little shot a little improvement So in summary what is prolonged for three main things stem cell-based rejuvenation are healthy aging Might my shoulder went bad Doctors couldn't do anything was inoperable They wanted to just give me steroid shots twice a year for the rest of my life. I Mean I can't do that But the stem cells can fix the wear and tear of our bodies Helps maintain your metabolic health. I just went through all those slides and they're far more on the website FMD Weight loss fastest way to lose weight. It's fat driven. You're not losing muscle. You're protecting your lean bottle body mass Actually, let's hang out there for a moment So dr. Longo's FMD kit is sold by a nonprofit company called Prolon All profits from Prolon go into the create cures foundation Which is dedicated to donating funds for research and development The focuses on identifying strategies to prevent illness and promote longer healthier lives through direct research Non-profits and charities. He does not personally profit from sales Prolon's FMD kit is gluten-free and non-gmo, but it contains nuts The kit includes everything you need for a five-day FMD cycle. It's seamless tasty and easy But it costs two hundred forty nine dollars Just does not fit my budget. I bought a kit and my first FMD went very smoothly My stomach didn't even growl till the evening of the third night For two hundred fifty dollars. I followed that thing to a tee. I made I added the right amount of glycerin to my water and tea I ate all the food Partition for that day and I limited my exercise Mentally, it wasn't anywhere near as tough as I imagined and expected I Decided that I wanted to see and I have MS and I get dizzy easily. I I really Didn't expect to feel as okay as I did during it, but it worked well I focused on the fact that it's only five days long. I do get to eat I could do it additional FMDs have been far far easier for me to finish again Confidence with my first one that I could successfully complete it and that success has helped immensely with my future past Let's talk about my results So you saw the clinical trial results of Groups of people. I think it was about 70 people my personal results. I lost four to eight pounds during each FMD diet cycle five-day cycle Unfortunately the restrictions of FMD and living through one of the most stressful years of my life Gave me the mental freedom to loosen up my normal diet Making my diet yo-yo monthly with each FMD However without FMD. I'm convinced that my weight would have very likely ballooned this last year So I'd still argue that FMD was very helpful in me maintaining a Good weight stable weight overall I want to talk a moment about my friend Susan an online friend who's had extraordinary results with FMD She used it to better tolerate her chemotherapy At her oncologist was shocked at how well she recovered from her treatments FMD allowed her to continue chemo while strengthening her joints Eliminating her neuropathy and maintaining energy that was impossible during chemo before fasting Additionally my 48 year old friend lost over a hundred pounds in just five months with a combined FMD and Pescatarian diet prescribed exactly as dr. Longo recommends Back to me though. We'll come back to her a little bit later I had mild asthma was just diagnosed a few years ago had never even had an asthma attack So I was comfortable skipping my asthma pill for the duration of the fast It's during the fast you don't take your normal supplements pills sort of things because you don't want to interfere with the nutritional pathways and activate things that You don't want activated So after the first fast however, I forgot to take my asthma pill Normally, I would wheeze when I was due for that pill, but after my first FMD. I stopped wheezing It's pretty sweet. It's very annoying to have a wheeze like that That was so exciting after my second FMD my partially torn rotator cuff had healed enough that I could lift things Over my head again without pain for the first time in three years Full range of motion. It's all back Fantastic, I was hooked. How did my MS respond to FMD? honestly My MS was so active when I was first diagnosed 15 years ago that I take the most powerful MS medicine available and Fatigue is my only lingering symptom. I Wish I had a dramatic story to share with you today about my MS being helped by FMD But regardless, I'm really happy that it's tightly controlled The biggest problem I had was the price $250 a month for five days of fasting did not work for the budget I Rationalized that the first FMD should definitely be from Prolon to maximize the chances that I could successfully and very safely Complete it wanted to get the full benefits and reduce the risks After that first FMD. I had to look elsewhere for food Dr. Longo specifically states that people He does say people should not do homemade FMDs This has not been proven. Oh, sorry disclaimer while I followed Okay, you should not do homemade FMDs However Spending $250 for food for one person for only five days wasn't working for me so I made a homemade version and I just want to say the disclaimer here while I followed the principles of FMD This has not been proven has no association with El Nutra the company that makes the Prolon FMD my second month of FMD I tried a homemade version, but it had more raw vegetables than I could actually chew in a reasonable time I could even finish most of my meals I was full But it took so much energy to plan and shop and prepare and chew all that food Then I was really happy with not happy at all I liked the homemade version because I could finally eliminate the beans and nightshades from the meals But overall I did not want to repeat that version So looking for homemade FMD info I searched FMD DIY and I looked on Facebook groups reddit and Individual websites like quantified Bob calm. I Learned that some people are happy Kind of cool Some people are happy with the homemade FMD eating two avocados a day with two scoops of green drink powder and electrolytes I loved the simplicity of that, but it sounded so boring. I Found people having success with canned soup and I really enjoy that protocol It fits my needs and that it's simple affordable and being free. I Enjoy vegetable soup and I found some tasty organic ones whose macros fit the FM or match the FMD in December 2018 Prolon began selling a fast bar, which is essentially the nut-based breakfast L bar with 30 fewer calories 10 of these fast bars sell for $35 and I really enjoy them. I found food grade glycerin on Amazon and Organic mint tea at the grocery store Delicious nut-based crackers olives and dessert bars round out my meals I found that canned soup or frozen homemade soup works best with my lifestyle and needs the specific macros To recreate day one of Prolon's FMD our 1100 calories day one 10% of that is protein 56% fat and 34% carbs days two through five have 725 calories each day 9% is protein 44% fat and 47% carbs How do you approach your doctor about doing FMD? Since I have multiple sclerosis. I asked my neurologist He knows that I always prefer more natural options when available and he's been accepting of that for over a decade I loaned him Dr. Longo's book the longevity diet Anyone wants to take a look later and I marked the most relevant parts for him to read He said that he read big chunks of the book and he seemed impressed yet. He was not willing to agree. I should do it Clinical research on MS was only done on mice with their version of MS called EAE still prolonged fasting reduced the disease severity of all mice and Completely revert reversed symptoms in 20% of those mice Still my neurologist insisted FMD was not proven safe and MS patients. I Guess he didn't want the liability if there was a problem since I was otherwise in good health Despite his wishes. I proceeded carefully and had a great experience a few months later I saw my asthma doctor for follow-up appointment. I did the spiramity Spirometry flow volume breathing test and she said that my numbers looked great She said the same as three months before and that's when I admitted to her that I had been doing this fasting mimicking diet And then I admitted to her that I stopped taking my asthma pills two months earlier She was shocked. So I shared my whole story with her and she agreed that while I do FMD I don't need my asthma pill total success again. What about my eyes? It's a pretty stunning image. I put up there My light sensitivity continues to quickly worsen My retina photos appear unchanged from six months ago While I've been doing monthly FMD my ophthalmologist told me to keep doing what I'm doing Although I understand that fasting cannot fix faulty genetics Back to my friend Susan Susan she had this major transformation following dr. Longo's recommendations include including becoming pescatarian She found dr. Longo's work When she was going through chemotherapy for breast cancer just before prolonged release the FMD So she began fasting real fasting just water without telling her oncologist But her doctor was happily shocked to see that she was still functional after her chemo treatments her chemo gave her such profound Neuropathy in her feet that she unbeknownst to her oncologist did a three-day water fast Before her next chemo treatment and she continued for two more days of fasting after that treatment Her chemo induced foot neuropathy nearly vanished just 24 hours With with just 24 hours of fasting her IBS disappeared and her joint instability and pain healed a stunning if Susan's experience was Even she agrees that the very best result of FMD is that your body can target and kill cancer cells at the cellular level Can help you even avoid a dreaded cancer diagnosis So how many prolon cycles? Do they recommend in a year? The prolon clinical trials remember included three consecutive monthly five-day cycles They recommend that everyone who is able should complete one or two FMDs per year And those with autoimmunity should do monthly FMDs For metabolic syndrome They recommend three consecutive a starter of three consecutive months of FMD followed by a doctor's evaluation to decide how to proceed Prolon did a fantastic job of creating a simple plan to follow with variety and good taste Their kit also includes a 15-minute phone consultation to answer your specific questions and ensure that you're prepared for a successful Experience they can tell you which prescription medicines are safe to take and still get the optimal benefits If you have a medical condition though be sure to consult with your doctor before starting FMD Insulin-dependent diabetics are not able to do FMD at all I'm so thankful that I learned about dr. Longo's FMD and gave it a try During FMD my thinking is clear and my body feels refreshed I do it to give my body a change and to try to kill autoimmune and cancer cells And to produce the stem cells. I truly hoped it would fix my retinas and joint problems That's another health thing. I didn't talk about the joints Hope it would really fix my eyes though My symptoms continue to worsen with my eyes but I'm able The imaging appears unchanged with monthly FMDs over six months So I have some hope with my vision. We'll see how that goes I Feel good though knowing I've done everything in my power to try to improve my health I'm relieved to find I'm relieved that my asthma and rotator cuff are fixed. It's the best treatment ever I consistently lost four to six pounds per FMD cycle, but my stress level ultimately kept me from keeping that weight off nearly nine thousand practitioners Offer a prolon to their clients one of my doctors and one of my daughter's doctors each do FMD I encourage you to integrate it into your practice if you want to see global improvements in your patient's health Practitioners can learn more at the practitioner side of the website prolon pro comm FMD offers people the ability to take control and make dramatic improvements in their health a very special thank you Goes to my beautiful daughters who helps me create the slides for this presentation I could not have done it without them Because left to my own devices quite honestly the slides looked like they were made by a second grader Yay high school kids and I'll leave on this note as we open it up to questions as we all know during fasting you never trust a part Questions We'll take questions up here at the mic. We have about five six minutes. Thanks for your presentation. Thank you I Actually was sort of interested in FMD about three years ago And kind of thought about Putting the money into trying it out, but I'm kind of a do-it-yourself or kind of person So I immediately went to as you went to try to find websites with recipes and such Of the benefits that come from the FMD diet I suspect that all or most come from a pure fasting Rather than a fat a pure fasting water fasting And that the fasting mimicking diet and you can help me on this is primarily to help The stress the mental stress about Fasting I think it would release Relieve a little bit of the physical stress too Right, but part of that stress is involved with the benefits of fasting I think So Did did prolon? Obviously they gave you the blessing to use their slides and they don't want FMD used for The do-it-yourself version of it correct and yet you that's your because it's So expensive. That's your primary path. That's after I tried theirs twice then I Because my husband was not willing to Have me continue right right at all. Yeah, I'm not sure I had a question, but I okay I wanted to get a sense of the The process of the FMD And I'm glad to hear that they're nonprofit I for a long time. I was kind of bothered by the profiting off of a of a health benefit I agree and and and keeping it kind of a Package system which is akin to process food anyway, no, I agree. It's but I think it's freeze-dried soups I think that's about a good way to describe the package soups and things But they're good and the bars are macadamia nuts and honey and real ingredients and he has organic olives from Spain and Good things in there High quality. Hi. Thanks for your presentation. Just a couple quick questions. Yes one thing I was curious about is what eating type framework you use in between your fasting mimicking diet And the other part is just I assume you're familiar with Jason Fung's work. Oh, yes And talking about why FMD versus just a straight-up fast, which seems to also work really well for people Of course like my friend Susan. She just did straight fasting with extraordinary results I'm not Brave enough it took me a year to get to this point to start FMD Your first question, what's my normal diet when I'm not doing FMD Nine years ago went in a more paleo direction 80% paleo kind of thing Last couple months more more keto out of that but My that picture of the old man with the house burning that's that's kind of my health and so I've gotten lax and I think psychologically it's been really hard for me because I get in that FMD zone and I only eat those certain foods and I do fine But then when I'm like an OCD thing almost and then when I'm out of that I just have this free-for-all. Oh, well, I can have this extra stuff and that stuff. Yeah, I Love that. I'll repeat that into the microphone As she asked if that might be a natural hormon or hormonal response to fasting that you eat a lot of food and get really hungry Afterwards and I don't know that side of things well enough to give an answer But it sure makes sense and we always talk about feast or famine Swing this way or that way. Thank you more of a comment than a question, but I approach these things somewhat cynically and Walter Longo says that he will donate 60 the profits from his 60% share of El Nutra to the create cures foundation Which is his own foundation which funds his own lab which funds the R&D for Prolon and there's no financial statements available for El Nutra or That and he's never confirmed any such donations That's interesting Thank you. Any other questions? Thank you so much for coming this morning