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Ancient RNA Relics and Modern Drug Discovery

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Uploaded on Nov 15, 2010

Air date: Wednesday, April 21, 2010, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Category: Wednesday Afternoon Lectures
Description: Cells control the expression of thousands of genes in response to many chemical and physical signals. Until recently, it was believed that proteins were the near-exclusive mediators of genetic control processes involving metabolite sensing. We have discovered numerous examples of "riboswitches" that act as chemical sensors and as genetic switches. Most riboswitches have been discovered in bacteria, where they control approximately 3% of the genes in some species.

In many instances, riboswitches control the expression of genes encoding key metabolic enzymes. Therefore, compounds that misregulate riboswitch-controlled genes should be candidates for new antibacterial agents. Indeed, recent findings indicate that some riboswitch classes are novel drug targets. Prospects for the development of drugs that trigger riboswitch function will be discussed.

The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Author: Dr. Ronald Breaker, Yale University
Runtime: 01:10:23
Permanent link: http://videocast.nih.gov/launch.asp?1...

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