 Escherichia coli are one of the most important pathogenic bacteria commonly found in livestock and widely studied as an indicator that carries drug-resistant genes between humans, animals, and the environment. Antimicrobials used in the food chain, particularly in food-producing animals, are recognized as a significant contributor to the development and spread of antimicrobial resistance, AMR. High-to-moderate prevalence of ESBL producing E. Coli has been observed in various food-producing animals, and the highest resistance rates to tetracycline and ampicillin were detected in different farms in all geographical regions. Worldwide pandemic clones and high-risk zoonotic E. coli clones have been identified in most food producing animals, and some of these clones are already disseminated in different niches, such as the environment and humans. A better understanding of the epidemiology of E. coli and ESBL producing E. coli in livestock is urgently needed. This article was authored by Adriana Silva, Vanessa Silva, Jose Eduardo Pereira, and others. We are article.tv. Links in the description below.