 Metal nanoparticles have been used extensively in recent years due to their unique optical properties known as localized surface plasmids resonances, LSPR. Gold and silver are two of the most commonly used noble metals for plasmonic applications because they possess distinctive properties such as high refractive index and strong absorption of light at specific wavelengths. These properties can be harnessed to create highly sensitive and selective biosensors for detecting target molecules. This review discusses the synthetic methods available for producing AG nanoparticles, the different coatings that can be applied to them, and the combination of gold and silver nanoparticles for enhanced plasmonic biosensor performance. This article was authored by Alexis Lossow, Victoire Assela, Gabriel Boydolalon, and others.