 The review examined the current state of research into 3D printed materials and techniques used for the fabrication of orthodontic appliances. It found that there was some evidence available on materials properties that are clinically relevant, but that more research is needed to fully understand how these materials perform in real-world applications. Additionally, there is a need for further clinical trials to better understand the potential benefits and risks associated with using 3D printing technology in orthodontics. This article was authored by Cecilia Garacci, Giovanna Jielowski, Claudio D'Amico, and others.