 Digital Therapeutics DTX are emerging as a new form of therapeutic intervention. DTX delivers interventions directly to patients via an evidence-based, clinically evaluated software to treat, manage, or prevent diseases. DTX manifests in various forms including web-based applications, mobile applications on smart devices, virtual reality, and video games. These technologies have been approved by the Food and Drug Administration, FDA, as standalone treatments or in combination with conventional therapies to improve patient outcomes. This paper reviews the clinical landscape of DTX, summarizing FDA-approved products and their clinical use, overviewing more than 300 ongoing clinical trials, and discussing challenges for their clinical translation and strategies to overcome them. This article was authored by Filana Fan, Samir Mitrigotri, and Zongmin Zhao. We are article.tv, links in the description below.