 This paper presents a comprehensive diagnostic algorithm for chronic traumatic encephalopathy, C.T. It outlines the limitations of existing diagnostic criteria for traumatic encephalopathy syndrome, T.S. slash C.T. and suggests a new diagnostic protocol. This protocol includes a detailed medical history, psychiatric assessments, and blood and cerebrospinal fluid biomarkers. This article was authored by Ioannis Mavridis, Ioannamiruna Balmas, Alan Sciobica, and others.