 Abstract targeted chemotherapy has received widespread attention in cancer treatment due to its advantages in reducing the side effects of chemotherapeutics and improving therapeutic effects. However, safe and efficient delivery of therapeutic agents remains a major obstacle. To address this issue, researchers have developed an aptamer, functionalised triangle DNA origami, TOADI, which can deliver chemotherapeutic drugs, doxorubicin, DOX, and a photosensitiser, indocyanine green, ICG. This TOADI is capable of releasing both drugs and sensitises into the nucleus of tumour cells via the photothermal effect of ICG triggered by near-infrared, NIR, laser irradiation. Additionally, it can also be used to target tumour specifically while minimising systemic toxicity. Furthermore, TOADI can be used to monitor the progress of the treatment using fluorescent and photothermal imaging. Overall, this novel approach offers great potential for improved cancer therapies.