 When we look lung cancer, breast cancer, we see all the strides that they accomplished over the last 10 years. When it comes to brain tumor, the last FDA approved drug was almost 10 years ago. There is a huge feud and of unknowns in neuro-oncology. We're learning so much every day about how the brain behaves and all the genetic alterations when it comes to brain tumors and so now it's a much fast evolving feud. Over the last five years there's a huge change in how we treat brain tumors and now we know that genetic markers matter on how we treat this patient. So I think all the trials and new research is actually veering us toward a more individualized approach, actually looking at genetic markers to actually individualize the treatment based on what the patient needs and I think that's what people did for other types of cancers in the body and they had amazing response. We were lagging a little bit behind but I think now we're catching up. All the clinical trials that we're using today is leading us towards immunotherapy. So most of the clinical trials we're opening are looking into the use of immunotherapy, combining it with other agents or radiation to see if we can improve how patients survive. We know that the brain tumor environment is severely immune suppressed and for the reason if we can actually enhance the immune system by using immunotherapy agents we can actually wake the immune system so we can attack the tumor properly and that's actually what most of our trials are looking at right now. The future in your oncology is precision medicine which is combining the genetic markers that a patient have to individualize the approach and I think that's where we're moving forward. So that's why most of the clinical trials that we perform here and even across the country they're actually looking at genetic markers in combination with the treatment to see if we can predict response by finding biomarkers that in the future we could use even before doing the treatment to predict whether that the patient would respond or not to that treatment.