 Oxidized low-density lipoproteins, ox LDL, are a type of cholesterol found in the bloodstream that can cause damage to the arteries. This damage leads to the development of atherosclerosis, a condition where fatty deposits build up inside the artery walls. Ox LDL activates certain proteins on the surface of vascular wall cells, such as the lectin-like oxidized low-density lipoprotein receptor 1, LOX-1. LOX-1 is responsible for the accumulation of ox LDL in the arteries, leading to further damage. LOX-1 is also involved in the inflammation and proliferation of smooth muscle cells, which contribute to the narrowing of the arteries. LOX-1 is highly expressed in atherosclerotic lesions, suggesting its role in the disease's progression. Researchers have developed methods to block the activity of LOX-1, which could lead to new treatments for atherosclerosis. This article was authored by Angela Pirillo, Giuseppe Dunilow-Noata and Albarico Leigh Gicatopano. We are article.tv, links in the description below.