 Lung cancer is the most common form of cancer worldwide, making it an important area of research. Current treatments include surgery, radiation, chemotherapy, targeted therapies, and immunotherapy, but all of them come with varying degrees of success and side effects. Additionally, chemotherapy-based regimens have reached a therapeutic plateau, so new treatments are needed. Natural compounds such as Wurtmanin, Raskavatin, Cordyceps Militaris, Resveratrol, OSU03013, Maricitin, Berberine, and Antroquininol have shown promise in treating various forms of cancer, including non-small cell lung cancer. These compounds could be used alongside existing chemotherapy drugs to provide more effective treatment options. This article was authored by Huang Qiyong, Judith Tong, Chong Qifan, and others.