 The study compares commercially available diagnostic assays for the detection of SSC-associated autoantibodies in 347 patients from the Nigemigent Systemic Sclerosis cohort and found high agreement between the diagnostic methods for the SSC-specific autoantibodies listed in the ACR Euler criteria. However, a lower agreement was found for SSC-associated autoantibodies PMSCL and Q, as well as for the SSC-specific autoantibodies Fibrillarin and TH2. The data revealed that the presence of ATA, ARA and ACA is predominantly mutually exclusive, with only a fraction of the patients testing positive for both ATA and ARA. The study suggests that further standardization for low-prevalent SSC-specific and SSC-associated autoantibodies is needed to improve the added value of autoantibodies in diagnosis and prognosis of SSC. This article was authored by Winn and Alcoma, Hans Conan, Bridget E. Kustin and others.