 piezoelectric semiconductors, P.S. nanomaterials have been widely used as senosensitizers in sonodynamic therapy, STT. The unique physical and chemical properties of these materials allow them to be used as efficient agents for generating R.S. under ultrasonic irradiation. This review discusses the structure and properties of P.S. nanomaterials, the use in STT, and the potential applications of these materials in cancer treatment and antimicrobial applications. This article was authored by Yan Xiaojiao, Qian Huan, Xiao Di Zhong, and others.